[How to predict spontaneous resolution of early pregnancies?]

Assessment of early pregnancy is indicated in women with suspected abnormalities. It is based on biochemical assessment and on trans vaginal sonography. To identify clinical, biological and ultrasonographic parameters that are predictive of spontaneous pregnancy resolution. A prospective observational study was performed interesting women with a positive pregnancy test without visualization of the pregnancy on the initial scan. All parameters measured during the initial visit were tested by univariate and multivariate analysis to identify parameters predicting spontaneous resolution of pregnancy. A total of 2675 women were included in the study. In 94 cases [4%] the location of pregnancy was unknown. Univariate and multivariate analysis showed that four parameters contributed significantly to the predictive power of the logistic model: Absence of pain [p =0,036], endometrial thickness < … 12 mm [p =0,021], initial serum beta hCG level < 1000 UI/l [p =0,015] and progesterone level < 29 nmol/l [p <0,001]. Women with a high probability of spontaneous resolution of their pregnancies can benefit from a spaced monitoring until the rate of beta -hCG will be negative

[Iron status in pregnant women and its changes during preeclampsia]

Micronutrients or trace elements are minerals essential for growth and development of the body human. To analyze changes in normal pregnancy and during preeclampsia, serum iron and its main proteins: ferritin and soluble transferrin receptors. This is a prospective study of case- control study of 56 pregnant women and 30 non-pregnant women selected as controls. Pregnant women received a quarterly dosing parametres. The same assays were performed once in controls. The comparative assay of various parameters in normal pregnancy and in control women showed a significant decrease in serum iron from 1 to the third quarter, a slight decline in reserves ferritin in 1st and 2nd quarter increases and becomes significant in the third quarter and an increase of soluble receptors trasferrine during pregnancy, which becomes significant in the third quarter. We noted a disturbance of these parameters in preeclampsia. Iron is essential for fetal development. His involvement in several maternal- fetal complications is not to dismantle

Prediction of ectopic pregnancy in early pregnancy of unknown location

Women having pregnancies of unknown location [PUL] can be defined as those having positive pregnancy test when no pregnancy is visualized on transvaginal ultrasound [TVS]. To identify diagnostic parameters which are predictive of ectopic pregnancies in women with early pregnancies of unknown location. We undertook a prospective observational study of pregnant women with suspected early pregnancy complications. Ninety-four patients were classified as having a pregnancy of unknown location [PUL] by transvaginal ultrasound; blood sample was taken on presentation to measure the serum human chorionic gonadotrophin [,-HCG] and progesterone levels. All collected data were tested by univariate analysis and then analyzed in a stepwise procedure to form a logistic model for predicting ectopic pregnancy. A total of 2675 women were referred for suspected early pregnancy was unknown. Three parameters were found to be statistically significant for predicting ectopic pregnancy: progesterone level, vaginal bleeding associated with pain and the presence of free fluid in the pouch of Douglas. The overall model described by these variables offer a sensitivity of 79 %and a specificity of 59% in the prediction of ectopic pregnancy. Logistic regression model can help in the clinical decision-making in women with pregnancy of unknown location

Does the mode of delivery affect neonatal morbidity and mortality in very low-birth-weight infants?

Despite the great advances made in neonatal intensive care, one of the greatest challenges in perimatology today, remains the management of very low-birth-weight infants [VLWB]. To evaluate the impact of the mode of delivery on very low-birth-weight infants' survival and their outcome. We performed a retrospective comparative study in the department "B" of gynecology-obstetrics in collaboration with the neonatology department of the same centre during a 12-month period. The study population included mothers giving birth to infants weighing between 500 and 1500 grams, at gestational age > 26 weeks and an Apgar score >3 at one minute. All included cases were classified according to the way of delivery: vaginal delivery [Group A] giving birth to neonates of group 1 and cesarean section [group B] giving birth neonates in group 2. The study involved 69 women giving birth to 82 very low-birth-weight infants. Both groups of parturients were homogeneous and similar in age, parity, prenatal care and gestational age. No statistically significant difference was noticed in terms of morbidity and mortality in the very low-birth-weight infants of the two groups. A higher rate of cesarean sections was noticed in breech presentations [74%]. Systematic cesarean section does not guarantee better outcome for very low-birth-weight infants

[Prospective study of the contribution of hydrosonography in the exploration of the uterine cavity]

Recent developments in ultrasound have led to a new exploration technique: hydrosonography. To evaluate diagnostic performance of hysterosonography in the assessment of the uterine cavity, by comparing it with standard transvaginal ultrasound and particularly with diagnostic hysteroscopy. This is a prospective study over a period of nine months from 1st January to 30 September 2009. Transvaginal ultrasound was performed for all patients followed by hydrosonography then by diagnostic hysteroscopy. Sixty-two patients underwent three examinations. The mean age of our patients was 42.2 years. Bleeding disorders of the menstrual cycle were the most common reasons for seeking. Referring to the pathological examination, hysteroscopy is the most accurate technique in the diagnosis of endometrial hyperplasia and intracavitary masses, followed by hydrosonography then by transvaginal ultrasound. The concordance between hydrosonography and hysteroscopy in the diagnosis of submucosal fibroids and hyperplasia of the endometrium is very good [K> 0.8]. The hysterosonography seems a relevant exam, allowing a complete assessment of the uterine cavity

[Pregnancy of unknown location]

A pregnancy of unknown location is a descriptive term that can be defined after performing trans vaginal ultrasound. This situation includes patients with a positive pregnancy test but with no evidence of intra or extra uterine pregnancy on transvaginal sonography. To discuss different aspects of management of women with pregnancy of unknown location. Review of the literature. Serum human chorionic gonadotrophin levels, progesterone levels and mathematical models are helpful in the prediction of final outcome of pregnancy: intra uterine pregnancy, ectopic pregnancy, spontaneous resolution or persistent pregnancy of unknown location. Active expectant management of asymptomatic women with a pregnancy of unknown location has been shown to be safe. Surgical intervention [diagnostic laparoscopy and uterine curettage] to diagnose the location of the pregnancy should be restrictive

[Evaluation of different techniques for vaginoplasty in the treatment of the syndrome of Mayer-Rokitansky-Küster-Hauser]

Rokitansky syndrome is an utero-vaginal aplasia with a frequency of 1 / 5000 female births. To correct this anomaly whose prognosis is mainly functional and psychological numerous surgical techniques have been described. To report our experience about 13 patients with Rokitansky syndrome and having benefited from a vaginoplasty between 1993 and 2008 and to evaluate the results of the various anatomical techniques. This is a retrospective study of 13 patients who underwent a vaginoplasty in the center of maternity and neonatal units, over a period from December 1993 to April 2008. During this period, two operative techniques were used: the technique of Mac-Indoe and the technique of Davydov. The mean age at the time of surgery was 22 years [15 years-32 years]. In 6 patients operated using the technique of Davydov the average depth of neovagina was 6.83 cm, one treatment failure was noted. Among the 7 patients operated using the technique of Mac Indoe the average length of neovagina was 7 cm, 3 treatment failures were noted. It was noted that there was no failure of the anatomical results in patients who have had regular sex after surgery. It was noted that there was failure of the anatomical result in 4 of 9 patients who did not have sexual intercourse after the procedure regardless of the technique used, a failure rate of 44%.The choice of technique will be based on the experience of the teams as each technique has similar anatomical and functional results in the literature. Both anatomical and functional, the main factor that determines the success of treatment seems to be the motivation of the patient to have a married life and sexual relationship

[Hysteroscopic myomectomy]

Hysteroscopic resection of submucous myomas is a safe alternative to conventional surgery. To evaluate the anatomical and functional results of endoscopic resection of submucous myomas and to present the principle complications of this technique. This is a retrospective study performed in the department "B" of gynecology and obstetrics in maternity center of Tunis "La Rabta". It analyzes a series of 105 hysteroscopic resections of intracavitary fibroids during a period of 8 years from January 2003 to December 2010. The mean age of our patients was 41 years and 5 months. The most frequently reason for consultation was the disorder of the menstrual cycle type of menometrorrhagia [47.6%], menorrhagia [22.8%] and postmenopausal bleeding [11.4%]. Preoperative assessment of the fibroid was based on transvaginal ultrasound in all cases associated with diagnostic hysteroscopy in 51.4% of cases and with hydrosonography in 28.6% cases. The mean size of the fibroid was 3.08 cm. Type 0 myomas represented 42.8% of cases. The most frequent emplacement of the myoma was the anterior surface of the uterus [44.7%]. After surgery, the resection was considered as complete in 88 patients [83.8%], partial in 17 patients [16.2%] requiring a second operation. The functional result was good with disappearance of bleeding symptoms in 90% of cases after a mean follow up of 17 months. Hysteroscopic resection of sub mucosal fibroids is a technique that respects the uterine cavity with satisfactory functional results and low morbidity

[Safety of magnesium sulfate in severe preeclampsia]

Several observational studies and randomized trials have described the use of various regimens of magnesium sulfate to prevent or reduce the rate of seizures and complications in women with severe preeclampsia. To assess the validity of a service protocol in the management of severe pre-eclampsia all specifying the benefits, complications and side effects of magnesium sulfate. We have performed a retrospective descriptive study over two years [2009-2010] concerning 150 patients affected with severe preeclampsia in the department "B" of gynecology and obstetrics of the "Rabta" at the Centre of Maternity and Neonatology of Tunis [third level maternity]. The protocol consisted in the administration of 3 grammes of magnesium sulfate followed by intravenous dose of 1 g/hour associated with an anti-hypertensive treatment. One hundred and forty patients [93%] had 2 or more criteria of severity associated. Seventy-eight [52%] patients with severe preeclampsia have profited an anti-hypertensive treatment based on nicardipine associated with magnesium sulfate without notable secondary effects. In two cases [1.3%] an eclampsia was noted with magnesium sulfate, 27.4% of severe preeclampsia was noted at a term within 34 week of amenorrhea. Only one case of surdosage was noted in post partum. The use of magnesium sulfate in practice does not appear to increase the risk of complications or major side effects in the mother and fetus

Primary leiomyosarcoma of broad ligament

Primary broad ligament leiomyosarcoma [LMS] is an extremely rare tumor with few well-documented cases. We are aware of 15 previously reported observations. Aim: Report of a new case. In this report we report a case of a right pelvic sidewall leiomyosarcoma with involvement of the appendix in a 49-year-old woman. A hysterectomy, bilateral salpingo-oophorectomy, omentectomy and appendicectomy were done, without complications. The patient died five months later. The case illustrates the difficulty of correct diagnosis before intervention. On this occasion, review of the literature confirms that this site remains unusual and the management is difficult

Primary leiomyosarcoma of the vagina. Case report and literature review

The vast majority of primary vaginal cancers are squamous cell carcinoma. The leiomyosarcoma of the vagina is extremely rare neoplasm. It comprising 2% to 3% of vaginal malignancies. Only 77 cases have been reported up to date in Anglo-Saxon literature. Report of a new case. We report a case of a patient 43 years old, single and presented a tumor of 7 cm to the detriment of the posterior wall of the vagina. The treatment consisted of a radical colpohysterectomy followed by postoperative radiotherapy. After 40 months, she is still alive without local or distant recurrence. This is a rare observation. The surgery is the basic treatment, the poor prognosis of these tumors remains linked especially to the histological grade